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99.536% · Kovera Labs · 2026-06-16Report KVR-2026-814088 · 50mg
For research use only — not for human or animal use.
Longevity
SS-31
$155.00
Strength · 50mg
SS-31 is a mitochondria-targeted peptide studied for its association with cardiolipin and its role in models of mitochondrial function.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
SS-31 (elamipretide) is a synthetic aromatic-cationic tetrapeptide of the Szeto-Schiller family, engineered from an opioid-peptide analog but reworked to eliminate opioid activity while retaining an aromatic-cationic motif for mitochondrial targeting. It carries a net positive charge and alternates cationic and aromatic residues.
It is a focused reference in longevity study, characterized for its association with cardiolipin and its role in models of mitochondrial function.
Research Focus
- Mitochondrial-myopathy models
- Cardiac and heart-failure models
- Ischemia-reperfusion-injury models
- Retinal-disease models
- Renal and aging / sarcopenia models
Mechanism
SS-31 does not bind a protein receptor; instead it is characterized as binding directly and reversibly to cardiolipin in the inner mitochondrial membrane, where it concentrates strongly by electrostatic and hydrophobic interactions independent of membrane potential.
By stabilizing cardiolipin it is reported to preserve electron-transport-chain organization and cristae structure, inhibit the permeability-transition pore, and engage Nrf2/SIRT1/PGC-1α signaling — with little effect on healthy mitochondria.
Molecular Profile
- Sequence
- D-Arg-Dmt-Lys-Phe-NH₂ (Dmt = 2′,6′-dimethyltyrosine)
- CAS number
- 736992-21-5
- Also known as
- Elamipretide, MTP-131, SS-31
Storage & Handling
Store research-grade lyophilized peptide at −20°C to −80°C, desiccated and protected from light and heat. Reconstituted solution is held refrigerated.
References
- Szeto HH. First-in-class cardiolipin-protective compound to restore mitochondrial bioenergetics. Br J Pharmacol. 2014.
- Birk AV, et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin. J Am Soc Nephrol. 2013.
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