Longevity Research
Epithalon 40mg
40mg
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly), the synthetic analog of the pineal-gland extract epithalamin, developed at the…
$155.00
The Collection
Front
Third-party testedComplimentary U.S. shippingShips in 24–48h
Longevity
MOTS-C
$150.00
Strength · 40mg
MOTS-c is a mitochondrial-derived peptide studied for its role in metabolic- and cellular-energy signaling research.
1
- Bulk
- 5+ vials — 5% · 10+ vials — 10% preferred rate
- Shipping
- Complimentary U.S. shipping
- Payment
- Card · Zelle · Venmo · Cash App
Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene — unusual in being encoded by mitochondrial rather than nuclear DNA. It is a linear, amphipathic, cationic peptide, and a natural polymorphism in its sequence has been associated with exceptional longevity in some populations.
It is a modern reference standard in the longevity category, studied for its role in metabolic- and cellular-energy signaling.
Research Focus
- Metabolic-disorder and diabetes models
- Exercise-physiology / exercise-mimetic research
- Aging and longevity models
- Vascular-calcification and bone-metabolism models
- Immunomodulation and neuroprotection research
Mechanism
MOTS-c functions as a 'mitokine' and metabolic regulator. Its primary characterized pathway inhibits the folate cycle, causing AICAR accumulation that activates AMPK — associated with fatty-acid oxidation and glucose uptake.
Under metabolic stress it is reported to translocate to the nucleus and bind antioxidant-response elements via Nrf2, alongside engagement of SIRT1/PGC-1α mitochondrial-biogenesis signaling.
Molecular Profile
- Also known as
- Mitochondrial ORF of the 12S rRNA type-c (MT-RNR1-encoded, 16 aa)
Storage & Handling
Store the lyophilized powder well below freezing, desiccated. Reconstituted solution is held near 4°C briefly or aliquoted and frozen; note that the peptide shows marked plasma instability.
References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical decline and muscle homeostasis. Nat Commun. 2021.
Related Research
Often explored alongside
Longevity Research
FOXO4 10mg
10mg
FOXO4-DRI is a synthetic, cell-permeable D-retro-inverso peptide — assembled from D-amino acids in reversed sequence for protease…
$180.00
Longevity Research
Glutathione 1500mg
1500mg
Glutathione is a naturally occurring, water-soluble tripeptide of glutamate, cysteine, and glycine, distinguished by an unusual…
$110.00
Longevity Research
NAD+ 1000mg
1000mg
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell — a dinucleotide that shuttles electrons through…
$155.00