Longevity
Epithalon
40mg
$123.75$165.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Longevity
MOTS-C
$127.50$170.00
Strength · 40mg
MOTS-c is a mitochondrial-derived peptide studied for its role in metabolic- and cellular-energy signaling research.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene — unusual in being encoded by mitochondrial rather than nuclear DNA. It is a linear, amphipathic, cationic peptide, and a natural polymorphism in its sequence has been associated with exceptional longevity in some populations.
It is a modern reference standard in the longevity category, studied for its role in metabolic- and cellular-energy signaling.
Research Focus
- ✦Metabolic-disorder and diabetes models
- ✦Exercise-physiology / exercise-mimetic research
- ✦Aging and longevity models
- ✦Vascular-calcification and bone-metabolism models
- ✦Immunomodulation and neuroprotection research
Mechanism
MOTS-c functions as a 'mitokine' and metabolic regulator. Its primary characterized pathway inhibits the folate cycle, causing AICAR accumulation that activates AMPK — associated with fatty-acid oxidation and glucose uptake.
Under metabolic stress it is reported to translocate to the nucleus and bind antioxidant-response elements via Nrf2, alongside engagement of SIRT1/PGC-1α mitochondrial-biogenesis signaling.
Molecular Profile
- Also known as
- Mitochondrial ORF of the 12S rRNA type-c (MT-RNR1-encoded, 16 aa)
Storage & Handling
Store the lyophilized powder well below freezing, desiccated. Reconstituted solution is held near 4°C briefly or aliquoted and frozen; note that the peptide shows marked plasma instability.
References
- Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015.
- Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical decline and muscle homeostasis. Nat Commun. 2021.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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