Explore compound 
Longevity research
MOTS-C
40 mg / $150.00
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene — unusual in being encoded by mitochondrial rather than nuclear DNA.
Available formats
Availability and final pricing are checked at checkout.
2 laboratory reports availableFor laboratory research use only. Not for human consumption.
A closer look
The details
behind the compound.
Overview
MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA gene — unusual in being encoded by mitochondrial rather than nuclear DNA. It is a linear, amphipathic, cationic peptide, and a natural polymorphism in its sequence has been associated with exceptional longevity in some populations.
It is a modern reference standard in the longevity category, studied for its role in metabolic- and cellular-energy signaling.
Laboratory documentation
Check the product format and report identifiers before comparing results. Available reports do not establish the lot currently held in stock.
Kovera Labs2026-06-16 · Analysis report99.566%Vanguard LaboratoryAnalysis report · Lot M26C40099.01%Research references
Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis. Cell Metab. 2015.
Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of physical decline and muscle homeostasis. Nat Commun. 2021.
Storage & handling
Store the lyophilized powder well below freezing, desiccated. Reconstituted solution is held near 4°C briefly or aliquoted and frozen; note that the peptide shows marked plasma instability.

