Longevity
Epithalon
40mg
$123.75$165.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Longevity
NAD+
$123.75$165.00
Strength · 1000mg
NAD+ is a fundamental coenzyme researched for its central role in cellular-energy and redox-signaling models.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell — a dinucleotide that shuttles electrons through central metabolism in its oxidized and reduced forms. First described in 1906, its tissue levels are documented to decline with age.
It is a foundational reference for cellular research, studied for its central role in energy metabolism and redox-signaling models.
Research Focus
- ✦Aging and longevity models
- ✦Metabolic and insulin-sensitivity models
- ✦Neurodegeneration models
- ✦Cardiovascular and vascular-aging models
- ✦DNA-repair and immune-modulation research
Mechanism
Beyond its redox role, NAD+ serves as a substrate for the sirtuin deacylases (associated with mitochondrial biogenesis and metabolic signaling), for PARP-mediated DNA-repair signaling, and for CD38 — a major regulator of tissue NAD+ that rises with age.
It is synthesized through de novo, Preiss-Handler, and — dominantly — salvage pathways, the latter rate-limited by the enzyme NAMPT.
Molecular Profile
- Molecular formula
- C21H27N7O14P2
- Molecular weight
- 663.43 g/mol
- CAS number
- 53-84-9
- Also known as
- Nicotinamide adenine dinucleotide
Storage & Handling
Store the powder at −20°C, protected from light and moisture. In aqueous solution it is characterized as stable at 4°C over roughly a month.
References
- Covarrubias AJ, et al. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021.
- Rajman L, et al. Therapeutic potential of NAD-boosting molecules: the in vivo evidence. Cell Metab. 2018.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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