Explore compound SS-31$155.00
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RESEARCH, REFINED.
The details
Considered compounds. Documented standards.Explore our standard
RESEARCH, REFINED.Longevity research
FOXO4
10 mg / $180.00
FOXO4-DRI is a synthetic, cell-permeable D-retro-inverso peptide — assembled from D-amino acids in reversed sequence for protease resistance — derived from the forkhead domain of the FOXO4 transcription factor and fused to a cell-penetrating domain.
Available formats
1
Availability and final pricing are checked at checkout.
1 laboratory report availableFor laboratory research use only. Not for human consumption.
A closer look
The details
behind the compound.
Overview
FOXO4-DRI is a synthetic, cell-permeable D-retro-inverso peptide — assembled from D-amino acids in reversed sequence for protease resistance — derived from the forkhead domain of the FOXO4 transcription factor and fused to a cell-penetrating domain. It was designed as a senolytic research tool.
It is a specialized reference for longevity laboratory work, studied for its interaction with the p53–FOXO4 pathway in cellular-senescence models.
- Molecular weight
- ≈5358 Da
- CAS number
- 2460055-10-9
Laboratory documentation
Check the product format and report identifiers before comparing results. Available reports do not establish the lot currently held in stock.
Vanguard LaboratoryAnalysis report · Lot F26C351View reportResearch references
Baar MP, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017.
Bourgeois B, et al. The disordered p53 transactivation domain is the target of FOXO4 and the senolytic FOXO4-DRI. Nat Commun. 2025.
Storage & handling
Store the lyophilized peptide at −20°C or lower for long-term stability. Reconstituted peptide is aliquoted, kept cold, and used promptly; avoid repeated freeze-thaw cycles.
