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Intimacy
Melanotan 2
$30.00$40.00
Strength · 10mg
Melanotan peptides are synthetic analogs of alpha-MSH researched for their role in melanocortin-receptor signaling models.
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Melanotan-2 is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone, synthesized at the University of Arizona for photoprotection research. A lactam-bridge cyclization and a D-phenylalanine substitution make it markedly more stable and potent than the native hormone and allow it to cross the blood-brain barrier.
It is an established reference in the radiance category, studied for melanocortin-receptor signaling and pigmentation-pathway behavior in laboratory settings.
Research Focus
- ✦Melanocortin-receptor pharmacology
- ✦Skin-pigmentation and photoprotection models
- ✦Energy-balance and appetite-signaling models
- ✦Neurobehavioral-signaling models
- ✦Nerve-regeneration research
Mechanism
Melanotan-2 acts as a non-selective agonist at the melanocortin receptors MC1R, MC3R, MC4R, and MC5R — all G-protein-coupled receptors — activating Gs-coupled adenylate cyclase and cAMP/PKA signaling.
Downstream effects are characterized as tissue-specific, including MC1R-driven melanogenesis signaling and central MC3R/MC4R engagement associated with energy-balance pathways.
Molecular Profile
- Sequence
- Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.2 g/mol
- CAS number
- 121062-08-6
- Also known as
- MT-II
Storage & Handling
Store the lyophilized powder at −20°C, dark, airtight, and protected from moisture. Reconstituted solution is held at 2–8°C and used within a few weeks; avoid repeated freeze-thaw.
References
- Dorr RT, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide, in a pilot phase-I study. Life Sci. 1996.
- Hruby VJ, et al. Cyclic lactam alpha-melanotropin analogues. J Med Chem. 1995.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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