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99.742% · Kovera Labs · 2026-06-23Report KVR-2026-E02D67 · 10mg
For research use only — not for human or animal use.
Recovery
KPV
$75.00
Strength · 10mg
KPV is a tripeptide fragment of alpha-MSH researched for its signaling role in models of cellular inflammation response.
1
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
KPV is a naturally occurring tripeptide corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone. It retains the anti-inflammatory character of the parent hormone while lacking its pigment-inducing activity — the compact 'active message sequence' first characterized in 1989.
It is a compact reference standard in the recovery category, studied for its signaling role in models of cellular inflammation response.
Research Focus
- Inflammatory-bowel and colitis models
- Dermatological-inflammation models
- Corneal and cutaneous wound-healing models
- Antimicrobial-activity research
- Joint- and pulmonary-inflammation models
Mechanism
Unlike alpha-MSH, KPV is characterized as not binding melanocortin receptors; instead it enters cells via the PepT1 peptide transporter, which is upregulated in inflamed tissue.
Once internalized it is reported to bind Importin-α3 to block nuclear import of NF-κB and to stabilize IκBα — a dual anti-inflammatory action — alongside inhibition of ERK, JNK, and p38 MAPK signaling.
Molecular Profile
- Sequence
- Lys-Pro-Val (K-P-V)
- Molecular weight
- 342.4 g/mol
- Also known as
- α-MSH(11–13)
Storage & Handling
Store the lyophilized peptide at −20°C for long-term stability. Reconstituted solution is held at 2–8°C for one to two weeks; avoid freeze-thaw and protect from light and moisture.
References
- Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008.
- Xiao B, et al. Orally targeted delivery of tripeptide KPV via hyaluronic-acid nanoparticles alleviates ulcerative colitis. Mol Ther. 2017.
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