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Recovery
THYMOSIN ALPHA-1
$80.00
Strength · 10mg
The Thymosin family comprises peptides studied for their roles in immune-signaling and cellular-organization research.
1
- Bulk
- 5+ vials — 5% · 10+ vials — 10% preferred rate
- Shipping
- Complimentary U.S. shipping
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Thymosin Alpha-1, or thymalfasin, is a highly conserved, acidic 28-amino-acid immunomodulatory polypeptide originally isolated from calf-thymus extract in 1977. It is the N-terminal fragment of the precursor prothymosin alpha, N-terminally acetylated and intrinsically disordered in solution.
It is among the most extensively characterized immune-signaling peptides in the literature and serves as an established reference across the recovery category.
Research Focus
- Chronic viral-infection models (hepatitis B and C)
- Oncology and immunotherapy-adjuvant models
- Sepsis and immune-restoration models
- Vaccine-adjuvant research
- Immune-reconstitution research
Mechanism
Thymosin Alpha-1 acts as an agonist of the pattern-recognition receptors TLR9 and TLR2 on dendritic cells, recruiting MyD88 and downstream NF-κB and MAPK signaling that has been associated with dendritic-cell maturation and cytokine expression.
The literature also characterizes a dual regulatory role, including induction of indoleamine 2,3-dioxygenase and tryptophan-catabolism signaling linked to immune tolerance.
Molecular Profile
- Sequence
- Ac-SDAAVDTSSEITTKDLKEKKEVVEEAEN-OH (28 aa)
- Molecular formula
- C₁₂₉H₂₁₅N₃₃O₅₅
- Molecular weight
- 3108.3 Da
- CAS number
- 62304-98-7
- PubChem CID
- 16130571
- Also known as
- Thymalfasin, Tα1, Talpha1
Storage & Handling
Store the lyophilized peptide refrigerated at 2–8°C, or at −20°C desiccated for long-term storage. Reconstituted solution is used promptly or held near 4°C for a few days.
References
- Goldstein AL, et al. Thymosin alpha1: isolation and sequence analysis of an immunologically active thymic polypeptide. PNAS. 1977.
- Romani L, et al. Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through toll-like receptor signaling. Blood. 2004.
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