Recovery
ARA-290
10mg
$48.75$65.00
The Collection
Front
✦Third-party tested✦American made✦Ships in 24–48h
Recovery
VIP
$56.25$75.00
Strength · 10mg
Vasoactive Intestinal Peptide is a signaling molecule researched for its role in neuroendocrine and vascular models.
1
- Bulk
- 5+ vials — 5% · 10+ vials — 10% preferred rate
- Shipping
- Complimentary US shipping over $200
- Payment
- Card · Zelle · Venmo · Cash App
✦
✦
✦
Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Vasoactive Intestinal Peptide is a 28-amino-acid neuropeptide of the glucagon–secretin superfamily, first isolated from porcine intestine in 1970 and highly conserved across mammals. Its synthetic form is known as aviptadil.
It is a versatile reference standard in cellular study, examined for signaling across neuroendocrine, vascular, and pulmonary models. It is an extremely labile peptide with a very short plasma half-life.
Research Focus
- ✦Respiratory and pulmonary-signaling models
- ✦Neurodegeneration and neuroprotection models
- ✦Inflammatory-bowel and colitis models
- ✦Pulmonary-hypertension and bronchodilation research
- ✦Circadian-rhythm regulation (suprachiasmatic nucleus)
Mechanism
VIP acts through the class-B G-protein-coupled receptors VPAC1 and VPAC2 (and, with lower affinity, PAC1). Canonical signaling proceeds through Gs, adenylyl cyclase, cAMP, and PKA, with tissue-specific alternative pathways including NF-κB modulation in immune cells.
Its serum half-life of roughly one to two minutes, driven by peptidase degradation, makes it a notably labile molecule requiring careful handling.
Molecular Profile
- Sequence
- His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂
- Molecular formula
- C₁₄₇H₂₃₈N₄₄O₄₂S
- Molecular weight
- 3326.8 Da
- CAS number
- 37221-79-7
- PubChem CID
- 16129630
- Also known as
- Vasoactive Intestinal Peptide, Aviptadil
Storage & Handling
Store the lyophilized peptide at −20°C, desiccated and protected from light. Given its extreme lability, reconstituted solution is best used without delay.
References
- Said SI, Mutt V. Polypeptide with broad biological activity: isolation from small intestine. Science. 1970.
- Langer I, et al. Signal transduction by VIP and PACAP receptors. Biochem Soc Trans. 2022.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
Continue Exploring
