Recovery
ARA-290
10mg
$48.75$65.00
The Collection
Front
✦Third-party tested✦American made✦Ships in 24–48h
Recovery
TB500
$108.75$145.00
Strength · 20mg
TB-500 is a synthetic fragment of the naturally occurring protein Thymosin Beta-4, studied for its role in actin regulation and cellular migration.
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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- Complimentary US shipping over $200
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
TB-500 is a synthetic, N-acetylated heptapeptide corresponding to the actin-binding domain (residues 17–23) of Thymosin Beta-4, a ubiquitous actin-regulating protein of the β-thymosin family. It retains the LKKTETQ motif that defines the parent molecule's interaction with the cytoskeleton.
It is a familiar reference within the recovery category, studied for its role in cell motility and tissue organization, and frequently examined alongside complementary repair-signaling peptides.
Research Focus
- ✦Dermal, corneal, and aged-wound repair models
- ✦Musculoskeletal (muscle, tendon, ligament) recovery
- ✦Cardiovascular and angiogenesis models
- ✦Neuroprotection and CNS-repair models
- ✦Actin sequestration and cytoskeletal biology
Mechanism
The LKKTETQ motif binds monomeric globular actin in a one-to-one complex, regulating actin polymerization and cytoskeletal organization — the basis of its documented influence on cell migration.
Research has additionally characterized interactions that engage Akt survival signaling, modulate NF-κB inflammatory signaling, and upregulate matrix metalloproteinases associated with tissue remodeling.
Molecular Profile
- Sequence
- Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)
- Molecular weight
- 889.0 g/mol
- CAS number
- 885340-08-9
- Also known as
- Thymosin β4 fragment (Tβ4 17–23), Fequesetide
Storage & Handling
Store the lyophilized powder at −20°C for long-term stability. Reconstituted solution is held at 2–8°C with a limited shelf life; avoid repeated freeze-thaw cycles.
References
- Philp D, et al. Thymosin β4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair. Wound Repair Regen. 2003.
- Esposito S, et al. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4. Drug Test Anal. 2012.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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