Longevity
FOXO4
10mg
$146.25$195.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Longevity
Epithalon
$123.75$165.00
Strength · 40mg
Epithalon is a synthetic tetrapeptide researched for its role in models of telomerase activity and cellular aging.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly), the synthetic analog of the pineal-gland extract epithalamin, developed at the St. Petersburg Institute of Bioregulation and Gerontology. It is the most extensively studied telomerase-associated geroprotective peptide and is characterized by an ultra-low-concentration response profile.
It is a central reference in the longevity category, studied for its role in models of telomerase activity and cellular aging.
Research Focus
- ✦Telomere-extension and cellular-senescence models
- ✦Cancer-prevention research
- ✦Retinal-degeneration models
- ✦Circadian-rhythm and melatonin regulation
- ✦Immune-rejuvenation and antioxidant research
Mechanism
Epithalon is characterized as operating through a receptor-independent, epigenetic mechanism — entering the nucleus, binding specific DNA sequences and histones, and decondensing chromatin so that silenced genes become transcribable.
It is reported to engage the hTERT promoter to upregulate telomerase, with downstream stimulation of melatonin synthesis, antioxidant defense, and circadian-clock genes.
Molecular Profile
- Sequence
- Ala-Glu-Asp-Gly (AEDG)
- Molecular weight
- 390.35 g/mol
- CAS number
- 307297-39-8
- Also known as
- Epitalon, AEDG peptide
Storage & Handling
Store the lyophilized peptide at −20°C, protected from moisture and light. Reconstituted solution is held near 4°C over the short term; avoid freeze-thaw cycles.
References
- Khavinson VK, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003.
- Anisimov VN, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in mice. Biogerontology. 2003.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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