Recovery
BPC-157
10mg
$48.75$65.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Recovery
ARA-290
$48.75$65.00
Strength · 10mg
ARA-290 is a synthetic peptide derived from the erythropoietin molecule, researched for its selective signaling through the innate-repair receptor.
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
ARA-290, also known as cibinetide, is a synthetic eleven-amino-acid peptide modeled on the helix-B surface domain of erythropoietin. Unlike full-length erythropoietin, it is non-hematopoietic — engineered to isolate the molecule's tissue-protective signaling from its blood-cell activity.
Research interest centers on its selective engagement of the innate repair receptor, a complex expressed by tissues under stress rather than at rest. It is offered strictly as a laboratory reference compound.
Research Focus
- ✦Neuropathic pain and small-fiber neuropathy models
- ✦Metabolic and insulin-signaling models
- ✦Cardiovascular and inflammatory-aging models
- ✦Tissue-protection and repair signaling
- ✦Mitochondrial and cytoprotection research
Mechanism
ARA-290 selectively binds the innate repair receptor — a heterocomplex of the erythropoietin receptor and the CD131 beta-common receptor — which is upregulated locally in response to injury, hypoxia, or metabolic stress rather than in healthy tissue. It does not engage the receptor form responsible for red-blood-cell production.
Receptor engagement has been characterized as initiating JAK2-mediated signaling across STAT, PI3K/Akt, and MAPK pathways, alongside attenuation of NF-κB-driven inflammatory signaling.
Molecular Profile
- Sequence
- Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
- Molecular formula
- C51H84N16O21
- Molecular weight
- 1257.3 g/mol
- CAS number
- 1208244-03-8
- PubChem CID
- 91810664
- Also known as
- Cibinetide, ARA290, pHBSP
Storage & Handling
Store the lyophilized peptide at −20°C, protected from light; refrigerated storage is stable over the medium term. Reconstituted solutions are held refrigerated at 2–8°C and used within weeks; avoid repeated freeze-thaw.
References
- Brines M, et al. Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin. PNAS. 2008.
- Swartjes M, et al. ARA290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain. Anesthesiology. 2011.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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