Cognitive
DSIP
10mg
$48.75$65.00
The Collection
Front
✦Third-party tested✦American made✦Ships in 24–48h
Cognitive
Semax
$37.50$50.00
Strength · 10mg
Semax is a synthetic peptide derived from a fragment of ACTH, researched for its role in neurotrophic and cognitive-signaling models.
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Semax is a synthetic heptapeptide derived from the ACTH(4-7) fragment of adrenocorticotropic hormone, extended with a Pro-Gly-Pro tail that makes it markedly more resistant to peptidase degradation. It is devoid of hormonal corticotropic activity and was developed at the Russian Academy of Sciences.
It is a leading reference in the cognitive category, studied for neurotrophic and neuroprotective signaling in laboratory models.
Research Focus
- ✦Ischemic-stroke models
- ✦Nootropic and cognitive-paradigm research
- ✦Optic-nerve and ophthalmic-neuropathy models
- ✦Neuroprotection and oxidative-stress models
- ✦Stress- and anxiety-model research
Mechanism
Semax has been characterized as strongly upregulating BDNF and NGF expression and stimulating TrkB phosphorylation, alongside modulation of dopaminergic and serotonergic systems and intracellular calcium under excitotoxic conditions.
Studies of ischemia-reperfusion report broad shifts in gene expression, upregulating neurotransmission-associated genes while downregulating pro-inflammatory ones.
Molecular Profile
- Sequence
- Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)
- Molecular weight
- 813.9 Da
- CAS number
- 80714-61-0
- Also known as
- ACTH(4-7)-Pro-Gly-Pro
Storage & Handling
Store the lyophilized powder at −20°C. Reconstituted solution is held at 2–8°C and protected from light; avoid repeated freeze-thaw.
References
- Dolotov OV, et al. Semax increases levels of BDNF protein in rat basal forebrain. J Neurochem. 2006.
- Eremin KO, et al. Semax activates dopaminergic and serotoninergic brain systems in rodents. Neurochem Res. 2005.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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