Cognitive
DSIP
10mg
$48.75$65.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Cognitive
Selank
$37.50$50.00
Strength · 10mg
Selank is a synthetic analog of the immunomodulatory peptide tuftsin, studied for its role in models of neurochemical balance.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Selank is a synthetic heptapeptide derived from the endogenous tetrapeptide tuftsin — a natural fragment of immunoglobulin G — extended with a Pro-Gly-Pro tail for enhanced metabolic stability. It was developed at the Russian Academy of Sciences and is noted for high intranasal bioavailability.
It is a defining reference within cognitive research, characterized for its stability and neurochemical-signaling profile.
Research Focus
- ✦Anxiety and neurasthenia models
- ✦Nootropic and memory-trace paradigms
- ✦Alcohol- and opioid-withdrawal models
- ✦Immunomodulation and antiviral research
- ✦Transcriptome-modulation studies
Mechanism
Selank is characterized as a positive allosteric modulator of the GABA-A receptor at a site distinct from the classical benzodiazepine site, together with inhibition of enkephalin-degrading enzymes that extends enkephalin signaling.
It has been reported to alter GABA-receptor subunit expression and elevate BDNF/TrkB signaling, modulating serotonin, norepinephrine, and dopamine region-specifically.
Molecular Profile
- Sequence
- Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)
- Molecular weight
- 751.9 Da
- CAS number
- 129954-34-3
- Also known as
- TP-7, tuftsin analog
Storage & Handling
Store the lyophilized powder at 4°C. Reconstituted solution is held at 2–8°C for roughly one month; avoid agitation.
References
- Vyunova TV, et al. Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity. Protein Pept Lett. 2018.
- Zozulya AA, et al. Efficacy and possible mechanisms of action of the peptide anxiolytic Selank. Zh Nevrol Psikhiatr. 2008.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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