Metabolic Research
5-Amino 1MQ 50mg
50mg
5-Amino-1MQ is a small-molecule methylquinolinium derivative — not a peptide — supplied as the iodide salt.
$75.00
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Lot T26C137
Vanguard LaboratoryReport V260204-18 · 60mg
For research use only — not for human or animal use.
Metabolic
GLP2-T
$260.00
GLP2-T is the house designation for a dual-agonist incretin-axis reference studied across GIP and GLP-1 receptor signaling.
1
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
GLP2-T is the house designation for a synthetic, acylated dual-agonist peptide of the incretin family — one engineered sequence that engages two receptor pathways at once: the glucose-dependent insulinotropic polypeptide receptor and the glucagon-like peptide-1 receptor.
Research interest centers on how a single molecule distributes activity across two related class-B receptors, and on how that balance reads against single-agonist reference peptides. It is offered strictly as a laboratory reference compound.
Research Focus
- Dual incretin-axis (GIP / GLP-1) receptor pharmacology
- Glycemic-handling and insulin-signaling models
- Energy-balance and satiety-signaling models
- Adipose- and hepatic-metabolism models
- Comparative potency against single-agonist references
Mechanism
GLP2-T is characterized as an agonist at two class-B G-protein-coupled receptors — GIPR and GLP-1R — each coupling principally through Gs, adenylyl cyclase, cAMP, and PKA. The literature treats the ratio between the two axes, rather than either in isolation, as the variable of interest, since both converge on overlapping metabolic signaling in islet and central models.
Fatty-acid acylation is the design feature that separates engineered multi-agonists from the native incretins their sequences are modeled on: albumin binding extends circulation and flattens the exposure profile of the unmodified peptides.
Molecular Profile
- Also known as
- Dual incretin-axis reference (GIPR / GLP-1R agonist)
Storage & Handling
Store the lyophilized peptide at −20°C, desiccated and protected from light; −80°C for the longest terms. Reconstituted solution is aliquoted, held at 2–8°C, and used within a short window; avoid repeated freeze-thaw.
References
- Finan B, et al. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med. 2013.
- Capozzi ME, et al. Targeting the incretin/glucagon system with triagonists to treat diabetes. Endocr Rev. 2018.
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