Metabolic Research
5-Amino 1MQ 50mg
50mg
5-Amino-1MQ is a small-molecule methylquinolinium derivative — not a peptide — supplied as the iodide salt.
$75.00
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Lot CG26C010
Vanguard LaboratoryReport V260205-13 · 10mg
For research use only — not for human or animal use.
Metabolic
Cagrilintide
$115.00
Strength · 10mg
Cagrilintide is a long-acting amylin analog studied for its role in satiety-signaling and metabolic research.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Cagrilintide is a long-acting, acylated analog of human amylin, engineered from the amylin scaffold with a fatty-diacid chain and anti-fibrillation substitutions that give it a multi-day half-life. It functions as a dual amylin- and calcitonin-receptor agonist.
It is a distinctive reference within the metabolic category, studied for its role in satiety-signaling and receptor-pharmacology models.
Research Focus
- Satiety- and energy-balance models
- Metabolic and glycemic-control models
- Amylin/calcitonin receptor pharmacology
- Combination-signaling research
- Structural-biology (receptor cryo-EM) research
Mechanism
Cagrilintide is characterized as a non-selective dual agonist of calcitonin receptors and amylin receptors — the latter being calcitonin-receptor/RAMP heterodimers. Receptor engagement activates Gs, adenylyl cyclase, and cAMP as the primary satiety-signaling cascade.
It is reported to bind via a receptor conformation with short residence time, characterized as limiting receptor desensitization.
Molecular Profile
- Molecular weight
- ≈4409 Da
- CAS number
- 1415456-99-3
- Also known as
- AM833, NN1213, long-acting amylin analog
Storage & Handling
Store the lyophilized peptide below freezing (−80°C for the longest terms, −20°C otherwise). Reconstituted solution is aliquoted and held frozen to limit degradation.
References
- Kruse T, et al. Development of Cagrilintide, a long-acting amylin analogue. J Med Chem. 2021.
- Lau DCW, et al. Once-weekly cagrilintide for weight management in people with overweight and obesity: a phase 2 trial. Lancet. 2021.
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