Metabolic Research
Cagrilintide 10mg
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Cagrilintide is a long-acting, acylated analog of human amylin, engineered from the amylin scaffold with a fatty-diacid chain and…
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Metabolic
5-AMINO-1MQ
$75.00
Strength · 50mg
5-Amino-1MQ is a small-molecule inhibitor studied for its interaction with the NNMT enzyme in cellular-metabolism research.
1
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
5-Amino-1MQ is a small-molecule methylquinolinium derivative — not a peptide — supplied as the iodide salt. It was rationally designed at the University of Texas Medical Branch as a membrane-permeable, selective inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT).
It is a focused reference for metabolic laboratory work, studied for its interaction with NNMT and downstream NAD-related pathways.
Research Focus
- Adipose-metabolism and fat-loss models
- Metabolic-syndrome and glucose-handling models
- Muscle-regeneration and sarcopenia models
- NAD⁺ / SIRT1 longevity signaling
- NNMT-overexpressing tumor models
Mechanism
5-Amino-1MQ is a substrate-competitive inhibitor of NNMT, competing with nicotinamide for the active site and blocking its SAM-dependent methylation. Inhibiting NNMT is characterized as preserving the intracellular nicotinamide pool — shunting it toward NAD⁺ salvage — while sparing methyl-donor capacity.
It is reported as selective for NNMT, without inhibition of related methyltransferases or the salvage enzyme NAMPT.
Molecular Profile
- Molecular formula
- C₁₀H₁₁IN₂ (iodide salt)
- Molecular weight
- 286.11 g/mol
- CAS number
- 42464-96-0
- PubChem CID
- 160243
- Also known as
- 5-AMQ, 5A-1MQ, NNMTi, 5-amino-1-methylquinolinium
Storage & Handling
Store the powder at −20°C (or 4°C short-term), protected from light and moisture. Prepared solutions are best held frozen. As a small molecule, it is not subject to peptide freeze-thaw sensitivity.
References
- Neelakantan H, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017.
- Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice. Biochem Pharmacol. 2018.
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