Radiance
GLOW
70mg
$101.25$135.00
The Collection
Front
✦Third-party tested✦American made✦Ships in 24–48h
Radiance
GHK-CU
$63.75$85.00
Strength · 100mg
GHK-Cu is a copper-binding tripeptide researched for its role in models of tissue-remodeling and skin-matrix signaling.
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
GHK-Cu is a naturally occurring tripeptide-copper complex — glycyl-L-histidyl-L-lysine chelated to a copper(II) ion — first isolated from human plasma in 1973. Its endogenous levels are documented to decline with age, and the bound copper gives the complex its characteristic blue-purple color.
It is a signature reference in the radiance category, studied for its role in models of tissue-remodeling and skin-matrix signaling.
Research Focus
- ✦Wound-healing and tissue-regeneration models
- ✦Skin extracellular-matrix and dermatology models
- ✦Hair-follicle research
- ✦Antioxidant and anti-inflammatory models
- ✦DNA-repair and gene-modulation research
Mechanism
GHK-Cu is characterized as a copper-delivery vehicle that 'redox-silences' the bound ion — supplying copper to enzymes such as lysyl oxidase and superoxide dismutase while limiting oxidative toxicity.
Gene-expression analyses describe it as a broad modulator, shifting expression across thousands of genes, with reported engagement of Nrf2/Keap1 antioxidant signaling and NF-κB/p38 MAPK modulation, alongside stimulation of extracellular-matrix synthesis.
Molecular Profile
- Sequence
- Gly-His-Lys · Cu²⁺
- Molecular weight
- ≈401.9 Da
- CAS number
- 89030-95-5
- Also known as
- Copper Tripeptide-1
Storage & Handling
Store the lyophilized powder at −20°C, protected from moisture. It is characterized as stable across a mildly acidic-to-neutral pH range and dissociates outside it; hold reconstituted solution cold.
References
- Pickart L, Margolina A. Regenerative and protective actions of the GHK-Cu peptide in light of new gene data. Int J Mol Sci. 2018.
- Pickart L, et al. Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells. Nature. 1980.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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