Growth
CJC (no DAC)
5mg
$30.00$40.00
The Collection
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✦Third-party tested✦American made✦Ships in 24–48h
Growth
Ipamorelin
$56.25$75.00
Strength · 10mg
Ipamorelin is a selective pentapeptide secretagogue studied for its targeted receptor activity in endocrine research.
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- 5+ vials — 5% · 10+ vials — 10% preferred rate
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue derived from the GHRP series, incorporating non-proteinogenic residues and a C-terminal amide. Developed at Novo Nordisk, it was the first secretagogue characterized for its selectivity of growth-hormone release.
It is valued in the laboratory for its well-defined receptor selectivity and is frequently paired with releasing-hormone analogs in comparative endocrine study.
Research Focus
- ✦Selective growth-hormone secretion physiology
- ✦Gastric motility models
- ✦Bone growth and metabolism
- ✦Body composition and adiposity models
- ✦Nociception and pain-modulation research
Mechanism
Ipamorelin is a selective agonist of the GHS-R1a (ghrelin) receptor on pituitary somatotroph cells. Receptor engagement activates phospholipase C signaling and intracellular calcium release that drives secretory-vesicle exocytosis — a pathway distinct from, yet synergistic with, GHRH signaling.
Characterization noted its selectivity relative to other secretagogues, without the prolactin or corticotropic activation seen with earlier peptides in the class.
Molecular Profile
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH₂
- Molecular formula
- C38H49N9O5
- Molecular weight
- 711.9 g/mol
- CAS number
- 170851-70-4
- Also known as
- NNC 26-0161
Storage & Handling
Store the lyophilized peptide at −18°C to −20°C, where it is stable for extended periods. Reconstituted solution is held refrigerated near 4°C for a few weeks; protect from light.
References
- Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998.
- Gobburu JVS, et al. Pharmacokinetic-pharmacodynamic modeling of ipamorelin in human volunteers. Pharm Res. 1999.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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