Growth
CJC (no DAC)
5mg
$30.00$40.00
The Collection
Front
✦Third-party tested✦American made✦Ships in 24–48h
Growth
Tesamorelin
$101.25$135.00
Strength · 20mg
Tesamorelin is a stabilized growth-hormone-releasing-hormone analog researched for its metabolic-signaling characteristics.
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- Bulk
- 5+ vials — 5% · 10+ vials — 10% preferred rate
- Shipping
- Complimentary US shipping over $200
- Payment
- Card · Zelle · Venmo · Cash App
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
Tesamorelin is a synthetic 44-amino-acid analog of growth-hormone-releasing hormone, distinguished by a trans-3-hexenoic acid group on the N-terminal tyrosine. This modification confers resistance to enzymatic degradation, extending its half-life well beyond that of native GHRH.
It serves as a precise reference standard within the growth category, studied for metabolic-signaling characteristics across adipose and endocrine models.
Research Focus
- ✦Visceral-adiposity and lipodystrophy models
- ✦Hepatic (NAFLD / NASH) and fibrosis models
- ✦Cognitive-function research
- ✦Peripheral nerve-regeneration models
- ✦Metabolic-syndrome and glucose-signaling models
Mechanism
Tesamorelin is a specific agonist of the GHRH receptor, a seven-transmembrane G-protein-coupled receptor on anterior-pituitary somatotroph cells. Activation signals through Gsα, adenylyl cyclase, cAMP, and PKA to promote secretion of stored growth hormone while preserving natural pulsatile release.
It is characterized as selective for the GHRH receptor, without engagement of the ghrelin receptor and without significant effect on other pituitary axes.
Molecular Profile
- Sequence
- hexenoyl-YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH₂ (44 aa)
- Molecular formula
- C₂₂₁H₃₆₆N₇₂O₆₇S
- Molecular weight
- 5135.9 Da
- CAS number
- 218949-48-5 (free base)
- PubChem CID
- 16137828
- Also known as
- TH9507, Hex-hGRF
Storage & Handling
Store the lyophilized peptide refrigerated at 2–8°C, protected from light. Reconstituted solution is held cool and used within its characterized stability window.
References
- Falutz J, et al. Metabolic effects of a growth hormone-releasing factor in patients with HIV. N Engl J Med. 2007.
- Falutz J, et al. Effects of tesamorelin (TH9507) on excess abdominal fat: pooled analysis of two Phase 3 trials. J Clin Endocrinol Metab. 2010.
✦Every vial ships with third-party HPLC verification; certificates of analysis are available on request.
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