Growth Research
CJC (no DAC)/Ipamorelin 5mg/5mg
5mg/5mg
Ipamorelin is a selective pentapeptide secretagogue studied for its targeted receptor activity in endocrine research.
$75.00
The Collection
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Certificates of analysis are issued per lot and available on request for this compound.
Growth
CJC (NO DAC)
$50.00
Strength · 5mg
CJC-1295 is a synthetic growth-hormone-releasing-hormone analog researched for its extended half-life and its effect on pulsatile signaling in endocrine models.
1
- Bulk
- 5+ vials — 5% · 10+ vials — 10% preferred rate
- Shipping
- Complimentary U.S. shipping
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Research Notice
For laboratory research use only. Not for human consumption.
The Dossier
Research Notes
CJC-1295 (no DAC), also known as Modified GRF(1-29), is a synthetic 29-amino-acid analog of growth-hormone-releasing hormone. It is a tetrasubstituted derivative of the GRF(1-29) sequence, modified at four positions to resist enzymatic degradation while retaining a short half-life and pulsatile signaling character.
It is a standard reference within the growth category, distinguished from the DAC-conjugated form by its lack of the albumin-binding linker.
Research Focus
- Body-composition and muscle-hypertrophy models
- Lipid-metabolism models
- Connective-tissue and injury-recovery models
- Slow-wave-sleep physiology
- Somatopause and cellular-function research
Mechanism
CJC-1295 (no DAC) is a selective agonist of the GHRH receptor, a class-B G-protein-coupled receptor on anterior-pituitary somatotroph cells. Engagement activates Gs, adenylyl cyclase, cAMP, and PKA signaling associated with pulsatile growth-hormone secretion.
The four amino-acid substitutions — including the D-Ala² position — are characterized as preventing enzymatic cleavage while preserving high homology with native GHRH.
Molecular Profile
- Sequence
- Tetrasubstituted GHRH(1–29): D-Ala², Gln⁸, Ala¹⁵, Leu²⁷
- Molecular weight
- ≈3368 Da
- CAS number
- 863288-34-0
- Also known as
- Modified GRF(1-29), Mod GRF 1-29, CJC-1295 without DAC
Storage & Handling
Store the lyophilized peptide at −20°C (or 2–8°C short-term). Reconstituted solution is held at 2–8°C over the medium term; avoid freeze-thaw cycles.
References
- Teichman SL, et al. Prolonged stimulation of GH and IGF-I secretion by CJC-1295 in healthy adults. J Clin Endocrinol Metab. 2006.
- Jetté L, et al. Identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005.
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